Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus r...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Hanson, M N, Preheim, L C, Chou, S, Talarico, C L, Biron, K K, Erice, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162714/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7625819/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.5.1204
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