Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.
Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus r...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162714/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7625819/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.5.1204 |
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