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Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers

The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness of intestinal adenomas of Apc(Min/+) (Min) mice was enhanced by deficiency for p53. In addition, the...

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Detalhes bibliográficos
Main Authors: Halberg, Richard B., Katzung, Darren S., Hoff, Peter D., Moser, Amy R., Cole, Carolyn E., Lubet, Ronald A., Donehower, Lawrence A., Jacoby, Russell F., Dove, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16262/
https://ncbi.nlm.nih.gov/pubmed/10716720
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