Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

NF-κB is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, and proliferative responses, yet the relevance of NF-κB signaling in muscle physiology and disease is less well documented. Here we show that muscle-restricted NF-κB inhibition in mice, through targeted...

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Main Authors: Mourkioti, Foteini, Kratsios, Paschalis, Luedde, Tom, Song, Yao-Hua, Delafontaine, Patrick, Adami, Raffaella, Parente, Valeria, Bottinelli, Roberto, Pasparakis, Manolis, Rosenthal, Nadia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2006
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626136/
https://ncbi.nlm.nih.gov/pubmed/17080195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28721
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