Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones.

Laboratory-derived fluoroquinolone-resistant mutants were created by serially passaging wild-type Pseudomonas aeruginosa on fluoroquinolone-containing agar to obtain high-level fluoroquinolone resistance (e.g., ciprofloxacin MIC of 1,024 micrograms/ml). With increases of 4- to 32-fold in MICs of flu...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Zhanel, G G, Karlowsky, J A, Saunders, M H, Davidson, R J, Hoban, D J, Hancock, R E, McLean, I, Nicolle, L E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162565/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7726519/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.2.489
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