Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones.

Laboratory-derived fluoroquinolone-resistant mutants were created by serially passaging wild-type Pseudomonas aeruginosa on fluoroquinolone-containing agar to obtain high-level fluoroquinolone resistance (e.g., ciprofloxacin MIC of 1,024 micrograms/ml). With increases of 4- to 32-fold in MICs of flu...

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Main Authors: Zhanel, G G, Karlowsky, J A, Saunders, M H, Davidson, R J, Hoban, D J, Hancock, R E, McLean, I, Nicolle, L E
格式: Artigo
語言:Inglês
出版: 1995
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC162565/
https://ncbi.nlm.nih.gov/pubmed/7726519
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