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Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

Proteolipid protein (PLP)-139–151 is the dominant encephalitogenic peptide that induces experimental autoimmune encephalomyelitis (EAE) in SJL (H-2(s)) mice. To examine the contribution of T cell receptor (TCR) specificity in the induction of EAE, we generated transgenic mice expressing the rearrang...

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Detalhes bibliográficos
Main Authors: Waldner, Hanspeter, Whitters, Matthew J., Sobel, Raymond A., Collins, Mary, Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16253/
https://ncbi.nlm.nih.gov/pubmed/10737797
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