Single amino acid replacements at positions altered in naturally occurring extended-spectrum TEM beta-lactamases.

By directed mutagenesis, we constructed a set of seven TEM-1 derivatives containing single replacements in each one of the amino acids substituted in naturally occurring extended-spectrum TEM beta-lactamases. The exact contribution of each mutation to the resistance phenotype was determined. In addi...

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Detalles Bibliográficos
Main Authors: Blazquez, J, Morosini, M I, Negri, M C, Gonzalez-Leiza, M, Baquero, F
Formato: Artigo
Idioma:Inglês
Publicado: 1995
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC162500/
https://ncbi.nlm.nih.gov/pubmed/7695296
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