Single amino acid replacements at positions altered in naturally occurring extended-spectrum TEM beta-lactamases.

By directed mutagenesis, we constructed a set of seven TEM-1 derivatives containing single replacements in each one of the amino acids substituted in naturally occurring extended-spectrum TEM beta-lactamases. The exact contribution of each mutation to the resistance phenotype was determined. In addi...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Blazquez, J, Morosini, M I, Negri, M C, Gonzalez-Leiza, M, Baquero, F
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7695296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.1.145
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