Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.

9-(2-Phosphonomethoxyethyl)adenine (PMEA) is an acyclic adenine nucleotide analog which exhibits potent and selective antiviral activity against herpesviruses and retroviruses. The study of [14C]PMEA uptake in HeLa S3 cells has shown that intracellular levels of the drug plateau after 1 h. Transport...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Cihlár, T, Rosenberg, I, Votruba, I, Holý, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7695292/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.1.117
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