In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine.

The efficacy of 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (S2242) was evaluated in several animal models for herpesvirus infections. Compound S2242 was more effective than acyclovir (i) when administered subcutaneously in a model for herpes simplex virus type 1 (HSV-1)-induced mortality in i...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Neyts, J, Jähne, G, Andrei, G, Snoeck, R, Winkler, I, De Clercq, E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7695329/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.1.56
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