Macromolecular mechanisms of sputum inhibition of tobramycin activity.

Tobramycin, an aminoglycoside antibiotic, is used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Tobramycin bioactivity, however, is antagonized by sputum. Glycoproteins (mucins) and high-molecular-weight DNA make up 2 to 3% (P. L. Masson and J. F. Heremans, p. 41...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Hunt, B E, Weber, A, Berger, A, Ramsey, B, Smith, A L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7535039/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.1.34
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