Macromolecular mechanisms of sputum inhibition of tobramycin activity.

Tobramycin, an aminoglycoside antibiotic, is used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Tobramycin bioactivity, however, is antagonized by sputum. Glycoproteins (mucins) and high-molecular-weight DNA make up 2 to 3% (P. L. Masson and J. F. Heremans, p. 41...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Hunt, B E, Weber, A, Berger, A, Ramsey, B, Smith, A L
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1995
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7535039/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.1.34
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