Macromolecular mechanisms of sputum inhibition of tobramycin activity.

Tobramycin, an aminoglycoside antibiotic, is used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Tobramycin bioactivity, however, is antagonized by sputum. Glycoproteins (mucins) and high-molecular-weight DNA make up 2 to 3% (P. L. Masson and J. F. Heremans, p. 41...

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Библиографические подробности

Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Hunt, B E, Weber, A, Berger, A, Ramsey, B, Smith, A L
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1995
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7535039/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.1.34
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