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Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia–telangiectasia (A-T), which is caused by mutations in the ATM gene. Through gene targeting, we have generated a line of Atm mutant mice, Atm(y/y) mice. In contr...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Borghesani, Paul R., Alt, Frederick W., Bottaro, Andrea, Davidson, Laurie, Aksoy, Saime, Rathbun, Gary A., Roberts, Thomas M., Swat, Wojciech, Segal, Rosalind A., Gu, Yansong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16240/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716718/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.050584897
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