Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia–telangiectasia (A-T), which is caused by mutations in the ATM gene. Through gene targeting, we have generated a line of Atm mutant mice, Atm(y/y) mice. In contr...

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Auteurs principaux: Borghesani, Paul R., Alt, Frederick W., Bottaro, Andrea, Davidson, Laurie, Aksoy, Saime, Rathbun, Gary A., Roberts, Thomas M., Swat, Wojciech, Segal, Rosalind A., Gu, Yansong
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2000
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC16240/
https://ncbi.nlm.nih.gov/pubmed/10716718
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