Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins

Intradermal vaccination by gene gun efficiently delivers DNA vaccines into DCs of the skin, resulting in the activation and priming of antigen-specific T cells in vivo. DCs, however, have a limited life span, hindering their long-term ability to prime antigen-specific T cells. We reason that a strat...

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Hlavní autoři: Kim, Tae Woo, Hung, Chien-Fu, Ling, Morris, Juang, Jeremy, He, Liangmei, Hardwick, J. Marie, Kumar, Sharad, Wu, T.-C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC162284/
https://ncbi.nlm.nih.gov/pubmed/12840065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317293
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