Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins

Intradermal vaccination by gene gun efficiently delivers DNA vaccines into DCs of the skin, resulting in the activation and priming of antigen-specific T cells in vivo. DCs, however, have a limited life span, hindering their long-term ability to prime antigen-specific T cells. We reason that a strat...

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Detalhes bibliográficos
Main Authors: Kim, Tae Woo, Hung, Chien-Fu, Ling, Morris, Juang, Jeremy, He, Liangmei, Hardwick, J. Marie, Kumar, Sharad, Wu, T.-C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC162284/
https://ncbi.nlm.nih.gov/pubmed/12840065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317293
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