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Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α

Previous investigations show that intracerebroventricular administration of a potent inhibitor of fatty acid synthase, C75, increases the level of its substrate, malonyl-CoA, in the hypothalamus. The “malonyl-CoA signal” is rapidly transmitted to skeletal muscle by the sympathetic nervous system, in...

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Detalhes bibliográficos
Main Authors: Cha, Seung-Hun, Rodgers, Joseph T., Puigserver, Pere, Chohnan, Shigeru, Lane, M. Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622837/
https://ncbi.nlm.nih.gov/pubmed/17030788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607334103
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