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Allosteric inhibition of Staphylococcus aureus d-alanine:d-alanine ligase revealed by crystallographic studies
d-alanine:d-alanine ligase (DDl) is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics. It catalyzes the formation of d-alanine:d-alanine dipeptide, sequentially by using one d-alanine and one ATP as substrates for the first-half reaction,...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1622796/ https://ncbi.nlm.nih.gov/pubmed/17015835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604905103 |
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