Allosteric inhibition of Staphylococcus aureus d-alanine:d-alanine ligase revealed by crystallographic studies

d-alanine:d-alanine ligase (DDl) is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics. It catalyzes the formation of d-alanine:d-alanine dipeptide, sequentially by using one d-alanine and one ATP as substrates for the first-half reaction,...

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Bibliographic Details
Main Authors: Liu, Shenping, Chang, Jeanne S., Herberg, John T., Horng, Miao-Miao, Tomich, Paul K., Lin, Alice H., Marotti, Keith R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622796/
https://ncbi.nlm.nih.gov/pubmed/17015835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604905103
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