Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

p19ARF has been implicated as a key regulator of p53 stability and activation. While numerous stresses activate the p53 growth arrest pathway, those requiring p19ARF remain to be elucidated. We used p19ARF knockout mouse embryo fibroblasts to show that DNA damage and microtubule disruption require p...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Khan, Shireen Hussain, Moritsugu, Janet, Wahl, Geoffrey M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.050560997
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