Critical Role for a Central Part of Mdm2 in the Ubiquitylation of p53

The stability of the p53 protein is regulated by Mdm2. By acting as an E3 ubiquitin ligase, Mdm2 directs the ubiquitylation of p53 and its subsequent degradation by the 26S proteasome. In contrast, the Mdmx protein, although structurally similar to Mdm2, cannot ubiquitylate or degrade p53 in vivo. T...

Descripció completa

Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Meulmeester, Erik, Frenk, Ruth, Stad, Robert, de Graaf, Petra, Marine, Jean-Christophe, Vousden, Karen H., Jochemsen, Aart G.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2003
Matèries:	Cell Growth and Development
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4929-4938.2003
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!