Critical Role for a Central Part of Mdm2 in the Ubiquitylation of p53

The stability of the p53 protein is regulated by Mdm2. By acting as an E3 ubiquitin ligase, Mdm2 directs the ubiquitylation of p53 and its subsequent degradation by the 26S proteasome. In contrast, the Mdmx protein, although structurally similar to Mdm2, cannot ubiquitylate or degrade p53 in vivo. T...

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Bibliographische Detailangaben
Hauptverfasser: Meulmeester, Erik, Frenk, Ruth, Stad, Robert, de Graaf, Petra, Marine, Jean-Christophe, Vousden, Karen H., Jochemsen, Aart G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC162227/
https://ncbi.nlm.nih.gov/pubmed/12832478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.4929-4938.2003
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