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Identification of residues contributing to the ATP binding site of Kir6.2

The ATP-sensitive potassium (K(ATP)) channel links cell metabolism to membrane excitability. Intracellular ATP inhibits channel activity by binding to the Kir6.2 subunit of the channel, but the ATP binding site is unknown. Using cysteine-scanning mutagenesis and charged thiol-modifying reagents, we...

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Autori principali: Trapp, Stefan, Haider, Shozeb, Jones, Phillippa, Sansom, Mark S.P., Ashcroft, Frances M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC162134/
https://ncbi.nlm.nih.gov/pubmed/12805206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg282
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