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The Largest Open Reading Frame (pks12) in the Mycobacterium tuberculosis Genome Is Involved in Pathogenesis and Dimycocerosyl Phthiocerol Synthesis

The cell wall lipids in Mycobacterium tuberculosis are probably involved in pathogenesis. The largest open reading frame in the genome of M. tuberculosis H37Rv, pks12, is unique in that it encodes two sets of domains needed to produce fatty acids. A pks12-disrupted mutant was produced, and disruptio...

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Udgivet i:Infect Immun
Principais autores: Sirakova, Tatiana D., Dubey, Vinod S., Kim, Hwa-Jung, Cynamon, Michael H., Kolattukudy, Pappachan E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Bacterial Infections
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161999/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12819062/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.7.3794-3801.2003
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