The Largest Open Reading Frame (pks12) in the Mycobacterium tuberculosis Genome Is Involved in Pathogenesis and Dimycocerosyl Phthiocerol Synthesis

The cell wall lipids in Mycobacterium tuberculosis are probably involved in pathogenesis. The largest open reading frame in the genome of M. tuberculosis H37Rv, pks12, is unique in that it encodes two sets of domains needed to produce fatty acids. A pks12-disrupted mutant was produced, and disruptio...

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Publicado en:	Infect Immun
Autores principales:	Sirakova, Tatiana D., Dubey, Vinod S., Kim, Hwa-Jung, Cynamon, Michael H., Kolattukudy, Pappachan E.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Bacterial Infections
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161999/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12819062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.7.3794-3801.2003
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