Overexpression of Interleukin-4 in Lungs of Mice Impairs Elimination of Histoplasma capsulatum

Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines. Since interleukin-4 (IL-4) can inhibit both Th1 cytokine production and activity, we examined the effects of overproduction of IL-4 in the lung on the course of pulmonary histoplasmosis. IL-4 lung transgenic mice...

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Pubblicato in:	Infect Immun
Autori principali:	Gildea, Lucy A., Gibbons, Reta, Finkelman, Fred D., Deepe Jr., George S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Fungal and Parasitic Infections
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12819061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.7.3787-3793.2003
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