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Overexpression of Interleukin-4 in Lungs of Mice Impairs Elimination of Histoplasma capsulatum

Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines. Since interleukin-4 (IL-4) can inhibit both Th1 cytokine production and activity, we examined the effects of overproduction of IL-4 in the lung on the course of pulmonary histoplasmosis. IL-4 lung transgenic mice...

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Detaylı Bibliyografya
Asıl Yazarlar: Gildea, Lucy A., Gibbons, Reta, Finkelman, Fred D., Deepe Jr., George S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2003
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC161995/
https://ncbi.nlm.nih.gov/pubmed/12819061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.7.3787-3793.2003
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