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Overexpression of Interleukin-4 in Lungs of Mice Impairs Elimination of Histoplasma capsulatum
Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines. Since interleukin-4 (IL-4) can inhibit both Th1 cytokine production and activity, we examined the effects of overproduction of IL-4 in the lung on the course of pulmonary histoplasmosis. IL-4 lung transgenic mice...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC161995/ https://ncbi.nlm.nih.gov/pubmed/12819061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.7.3787-3793.2003 |
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