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Accuracy of thymine–thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase η

The Saccharomyces cerevisiae RAD30 gene functions in error-free replication of UV-damaged DNA. RAD30 encodes a DNA polymerase, Pol η, which inserts two adenines opposite the two thymines of a cis-syn thymine–thymine (T–T) dimer. Here we use steady-state kinetics to determine the accuracy of DNA synt...

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Bibliografiske detaljer
Main Authors: Washington, M. Todd, Johnson, Robert E., Prakash, Satya, Prakash, Louise
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16198/
https://ncbi.nlm.nih.gov/pubmed/10725365
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