Intracellular Release of Nitric Oxide by NCX 972, an NO-Releasing Metronidazole, Enhances In Vitro Killing of Entamoeba histolytica

The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Sannella, Anna, Gradoni, Luigi, Persichini, Tiziana, Ongini, Ennio, Venturini, Giorgio, Colasanti, Marco
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821483/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.7.2303-2306.2003
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