Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid

Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of...

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Main Authors: Bulatovic, Vanja M., Wengenack, Nancy L., Uhl, James R., Hall, Leslie, Roberts, Glenn D., Cockerill III, Franklin R., Rusnak, Frank
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC127408/
https://ncbi.nlm.nih.gov/pubmed/12183226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.9.2765-2771.2002
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