Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid

Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Bulatovic, Vanja M., Wengenack, Nancy L., Uhl, James R., Hall, Leslie, Roberts, Glenn D., Cockerill III, Franklin R., Rusnak, Frank
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127408/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.2765-2771.2002
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