Allele-Specific rpoB PCR Assays for Detection of Rifampin-Resistant Mycobacterium tuberculosis in Sputum Smears

We describe an allele-specific PCR assay to detect mutations in three codons of the rpoB gene (516, 526, and 531) in Mycobacterium tuberculosis strains; mutations in these codons are reported to account for majority of M. tuberculosis clinical isolates resistant to rifampin (RIF), a marker of multid...

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Bibliographische Detailangaben
Hauptverfasser: Mokrousov, Igor, Otten, Tatiana, Vyshnevskiy, Boris, Narvskaya, Olga
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC161874/
https://ncbi.nlm.nih.gov/pubmed/12821473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.7.2231-2235.2003
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