Allele-Specific rpoB PCR Assays for Detection of Rifampin-Resistant Mycobacterium tuberculosis in Sputum Smears

We describe an allele-specific PCR assay to detect mutations in three codons of the rpoB gene (516, 526, and 531) in Mycobacterium tuberculosis strains; mutations in these codons are reported to account for majority of M. tuberculosis clinical isolates resistant to rifampin (RIF), a marker of multid...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Mokrousov, Igor, Otten, Tatiana, Vyshnevskiy, Boris, Narvskaya, Olga
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161874/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.7.2231-2235.2003
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