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De novo protein design: Crystallographic characterization of a synthetic peptide containing independent helical and hairpin domains
The Meccano (or Lego) set approach to synthetic protein design envisages covalent assembly of prefabricated units of peptide secondary structure. Stereochemical control over peptide folding is achieved by incorporation of conformationally constrained residues like α-aminoisobutyric acid (Aib) or dPr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC16187/ https://ncbi.nlm.nih.gov/pubmed/10725396 |
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