Calpain Mediates Calcium-Induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons : Relevance to Alzheimer’s Disease

Aberrant phosphorylation of the neuronal cytoskeleton is an early pathological event in Alzheimer’s disease (AD), but the underlying mechanisms are unclear. Here, we demonstrate in the brains of AD patients that neurofilament hyperphosphorylation in neocortical pyramidal neurons is accompanied by ac...

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Autori principali: Veeranna, Kaji, Takahide, Boland, Barry, Odrljin, Tatjana, Mohan, Panaiyur, Basavarajappa, Balapal S., Peterhoff, Corrinne, Cataldo, Anne, Rudnicki, Anna, Amin, Niranjana, Li, Bing Sheng, Pant, Harish C., Hungund, Basalingappa L., Arancio, Ottavio, Nixon, Ralph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2004
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618589/
https://ncbi.nlm.nih.gov/pubmed/15331404
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