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Cyclin-Dependent Kinase Inhibitors Attenuate Protein Hyperphosphorylation, Cytoskeletal Lesion Formation, and Motor Defects in Niemann-Pick Type C Mice

Dysregulation of cyclin-dependent kinases (cdks) and cytoskeletal protein hyperphosphorylation characterizes a subset of human neurodegenerative diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, and Niemann-Pick Type C (NPC). It is thought that these cytoskeletal changes lead e...

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Main Authors: Zhang, Min, Li, Jin, Chakrabarty, Paramita, Bu, Bitao, Vincent, Inez
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618588/
https://ncbi.nlm.nih.gov/pubmed/15331409
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