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The M184V Substitution in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Delays the Development of Resistance to Amprenavir and Efavirenz in Subtype B and C Clinical Isolates
The M184V substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), encoding high-level resistance to lamivudine (3TC), results in decreased HIV-1 replicative capacity, diminished RT processivity, and increased RT fidelity in biochemical assays. We assessed the effect o...
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Autori principali: | , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
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American Society for Microbiology
2003
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC161854/ https://ncbi.nlm.nih.gov/pubmed/12821504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.7.2376-2379.2003 |
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