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The M184V Substitution in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Delays the Development of Resistance to Amprenavir and Efavirenz in Subtype B and C Clinical Isolates

The M184V substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), encoding high-level resistance to lamivudine (3TC), results in decreased HIV-1 replicative capacity, diminished RT processivity, and increased RT fidelity in biochemical assays. We assessed the effect o...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Diallo, Karidia, Brenner, Bluma, Oliveira, Maureen, Moisi, Daniela, Detorio, Mervi, Götte, Matthias, Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821504/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.7.2376-2379.2003
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