Targeted Disruption of TGF-β/Smad3 Signaling Modulates Skin Fibrosis in a Mouse Model of Scleroderma

Transforming growth factor-β (TGF-β) is a potent stimulus of connective tissue accumulation, and is implicated in the pathogenesis of scleroderma and other fibrotic disorders. Smad3 functions as a key intracellular signal transducer for profibrotic TGF-β responses in normal skin fibroblasts. The pot...

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Autori principali: Lakos, Gabriella, Takagawa, Shinsuke, Chen, Shu-Jen, Ferreira, Ahalia M., Han, Gangwen, Masuda, Koichi, Wang, Xiao-Jing, DiPietro, Luisa A., Varga, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618525/
https://ncbi.nlm.nih.gov/pubmed/15215176
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