Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN

Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We previously described that lymphocyte-specific protein tyrosine kinase (LCK) and FYN oncogene related to SRC, FGR, YES (FYN) mediate GC-induced inhibition of T-cell-receptor (T...

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Bibliografiske detaljer
Main Authors: Löwenberg, Mark, Verhaar, Auke P, Bilderbeek, Joyce, Marle, Jan van, Buttgereit, Frank, Peppelenbosch, Maikel P, van Deventer, Sander J, Hommes, Daniel W
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Scientific Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618362/
https://ncbi.nlm.nih.gov/pubmed/16888650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400775
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