The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems

1. Several peptidic urotensin-II (UT) receptor antagonists exert ‘paradoxical' agonist activity in recombinant cell- and tissue-based bioassay systems, likely the result of differential urotensin-II receptor (UT receptor) signal transduction/coupling efficiency between assays. The present study...

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Detalhes bibliográficos
Main Authors: Behm, David J, Stankus, Gerald, Doe, Christopher P A, Willette, Robert N, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Nuthulaganti, Parvathi, Fornwald, James A, Ames, Robert S, Lambert, David G, Calo', Girolamo, Camarda, Valeria, Aiyar, Nambi V, Douglas, Stephen A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617064/
https://ncbi.nlm.nih.gov/pubmed/16547525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706716
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