The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems

1. Several peptidic urotensin-II (UT) receptor antagonists exert ‘paradoxical' agonist activity in recombinant cell- and tissue-based bioassay systems, likely the result of differential urotensin-II receptor (UT receptor) signal transduction/coupling efficiency between assays. The present study...

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Hauptverfasser: Behm, David J, Stankus, Gerald, Doe, Christopher P A, Willette, Robert N, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Nuthulaganti, Parvathi, Fornwald, James A, Ames, Robert S, Lambert, David G, Calo', Girolamo, Camarda, Valeria, Aiyar, Nambi V, Douglas, Stephen A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2006
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617064/
https://ncbi.nlm.nih.gov/pubmed/16547525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706716
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