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Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-κB inactivation
1. Buddlejasaponin IV isolated from Pleurospermum kamtschatidum is an anti-inflammatory compound that inhibits NO, PGE(2) and TNF-α production. Here, we studied the mode of action of this compound. 2. Buddlejasaponin IV (2.5–10 μM) reduced lipopolysaccaride (LPS (1 μg ml(−1)))-induced levels of iNOS...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1617058/ https://ncbi.nlm.nih.gov/pubmed/16520738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706718 |
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