Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-κB inactivation

1. Buddlejasaponin IV isolated from Pleurospermum kamtschatidum is an anti-inflammatory compound that inhibits NO, PGE(2) and TNF-α production. Here, we studied the mode of action of this compound. 2. Buddlejasaponin IV (2.5–10 μM) reduced lipopolysaccaride (LPS (1 μg ml(−1)))-induced levels of iNOS...

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Detalhes bibliográficos
Main Authors: Won, Jong-Heon, Im, Ho-Taek, Kim, Yang-Hee, Yun, Kyung-Jin, Park, Hee-Juhn, Choi, Jong-Won, Lee, Kyung-Tae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617058/
https://ncbi.nlm.nih.gov/pubmed/16520738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706718
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