Hyperactivation of p21(ras) and PI3K cooperate to alter murine and human neurofibromatosis type 1–haploinsufficient osteoclast functions

Individuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia. However, understanding of the cellular and molecular basis of these sequelae is incomplete. Osteoclasts are specialized myeloid cells that are the principal bone-resorbing cells of the skeleton. We...

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Autores principales: Yang, Feng-Chun, Chen, Shi, Robling, Alexander G., Yu, Xijie, Nebesio, Todd D., Yan, Jincheng, Morgan, Trent, Li, Xiaohong, Yuan, Jin, Hock, Janet, Ingram, David A., Clapp, D. Wade
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1616197/
https://ncbi.nlm.nih.gov/pubmed/17053831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29092
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