Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Genetic loss of surface Fas antigen expression leads to reduced apoptosis of myeloid and lymphoid progenitor cells, and a propensity to develop autoimmunity and myeloid leukemia in mouse models. Oncogenic p21(ras) decreases surface Fas antigen expression and renders fibroblasts resistant to Fas medi...

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Bibliografiske detaljer
Main Authors: Hiatt, Kelly, Ingram, David A., Huddleston, Hannah, Spandau, Dan F., Kapur, Reuben, Clapp, D. Wade
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2004
Fag:
Animal Model
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615352/
https://ncbi.nlm.nih.gov/pubmed/15039234
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