Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Genetic loss of surface Fas antigen expression leads to reduced apoptosis of myeloid and lymphoid progenitor cells, and a propensity to develop autoimmunity and myeloid leukemia in mouse models. Oncogenic p21(ras) decreases surface Fas antigen expression and renders fibroblasts resistant to Fas medi...

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Main Authors: Hiatt, Kelly, Ingram, David A., Huddleston, Hannah, Spandau, Dan F., Kapur, Reuben, Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2004
Assuntos:
Animal Model
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615352/
https://ncbi.nlm.nih.gov/pubmed/15039234
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