Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

The most common inherited form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting adult motoneurons, is caused by dominant mutations in the ubiquitously expressed Cu(2+)/Zn(2+) superoxide dismutase (SOD1). Recent studies suggest that glia may contribute to motoneuron injur...

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Detalhes bibliográficos
Main Authors: Beers, David R., Henkel, Jenny S., Xiao, Qin, Zhao, Weihua, Wang, Jinghong, Yen, Albert A., Siklos, Laszlo, McKercher, Scott R., Appel, Stanley H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1613228/
https://ncbi.nlm.nih.gov/pubmed/17043238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607423103
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