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Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter
The Pgp (P-glycoprotein) multidrug transporter couples ATP hydrolysis at two cytoplasmic NBDs (nucleotide-binding domains) to the transport of hydrophobic compounds. Orthovanadate (V(i)) and fluoroaluminate (AlF(x)) trap nucleotide in one NBD by forming stable catalytically inactive complexes (Pgp–M...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1609918/ https://ncbi.nlm.nih.gov/pubmed/16803457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060015 |
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