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Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function
Multidrug resistance in cancer is linked to expression of the P-glycoprotein multidrug transporter (Pgp, ABCB1), which exports many structurally diverse compounds from cells. Substrates first partition into the bilayer and then interact with a large flexible binding pocket within the transporter’s t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3939933/ https://ncbi.nlm.nih.gov/pubmed/24624364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00041 |
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