Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells.

P-Glycoprotein (Pgp) was isolated from CHRC5 membranes by selective detergent extraction and further purified by lentil lectin affinity chromatography. The purified product displayed a very high basal ATPase activity (1.65 mumol/min per mg protein in the absence of added drugs or lipids) with an app...

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Bibliographic Details
Main Authors: Sharom, F J, Yu, X, Chu, J W, Doige, C A
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136937/
https://ncbi.nlm.nih.gov/pubmed/7772017
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