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Statins inhibit the dimerization of β-secretase via both isoprenoid- and cholesterol-mediated mechanisms
We have previously reported that protein lipidation in the form of palmitoylation and farnesylation is critical for the production of Aβ (amyloid β-peptide), the dimerization of β-secretase and its trafficking into cholesterol-rich microdomains. As statins influence these lipid modifications in addi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1609905/ https://ncbi.nlm.nih.gov/pubmed/16803455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060655 |
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